Henry Brem Selected Research

poliferprosan 20 drug combination carmustine (Gliadel)

1/2019	Overall Survival in Malignant Glioma Is Significantly Prolonged by Neurosurgical Delivery of Etoposide and Temozolomide from a Thermo-Responsive Biodegradable Paste.
1/2016	The Johns Hopkins Hunterian Laboratory Philosophy: Mentoring Students in a Scientific Neurosurgical Research Laboratory.
12/2015	MGMT inactivation and clinical response in newly diagnosed GBM patients treated with Gliadel.
1/2015	Interstitial chemotherapy for malignant glioma: Future prospects in the era of multimodal therapy.
7/2010	Carmustine wafers (Gliadel) plus concomitant temozolomide therapy after resection of malignant astrocytoma: growing evidence for safety and efficacy.
3/2009	Gliadel (BCNU) wafer plus concomitant temozolomide therapy after primary resection of glioblastoma multiforme.
1/2009	Independent association of extent of resection with survival in patients with malignant brain astrocytoma.
10/2008	Use of Gliadel (BCNU) wafer in the surgical treatment of malignant glioma: a 10-year institutional experience.
5/2007	Interstitial chemotherapy for malignant gliomas: the Johns Hopkins experience.
1/2004	Clinical course and pathologic findings after Gliadel and radiotherapy for newly diagnosed malignant glioma: implications for patient management.

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Henry Brem Research Topics

Disease

95	Neoplasms (Cancer) 02/2022 - 02/2002
72	Glioma (Gliomas) 04/2022 - 02/2002
51	Brain Neoplasms (Brain Tumor) 01/2022 - 07/2002
35	Glioblastoma (Glioblastoma Multiforme) 02/2022 - 06/2002
23	Gliosarcoma 01/2022 - 02/2002
6	Melanoma (Melanoma, Malignant) 02/2022 - 12/2002
6	Wounds and Injuries (Trauma) 02/2021 - 05/2003
5	Meningioma (Meningiomas) 03/2022 - 06/2002
5	Astrocytoma (Pilocytic Astrocytoma) 11/2020 - 06/2002
5	Seizures (Absence Seizure) 08/2017 - 02/2005
4	Surgical Wound Infection 04/2022 - 10/2008
4	Infections 12/2020 - 01/2004
4	Pulmonary Embolism 10/2018 - 10/2008
4	Oligodendroglioma 09/2013 - 06/2002
3	Hydrocephalus (Hydrocephaly) 09/2022 - 01/2006
3	Hepatitis C 01/2020 - 01/2018
3	Breast Neoplasms (Breast Cancer) 01/2019 - 09/2007
3	Edema (Dropsy) 06/2018 - 07/2002
3	Neoplasm Metastasis (Metastasis) 12/2013 - 01/2004
3	Venous Thrombosis (Deep-Vein Thrombosis) 03/2013 - 10/2008
2	Hyperglycemia 04/2022 - 05/2010
2	Thrombosis (Thrombus) 01/2022 - 03/2009
2	Rhabdoid Tumor (Rhabdoid Tumors) 09/2021 - 01/2018
2	Hematologic Neoplasms (Hematological Malignancy) 02/2021 - 01/2020
2	Medulloblastoma 02/2021 - 01/2021
2	Pain (Aches) 10/2018 - 03/2007
2	Spinal Cord Neoplasms (Spinal Cord Tumors) 08/2015 - 08/2005
2	Corneal Neovascularization 01/2015 - 11/2005
2	Adenocarcinoma 11/2014 - 12/2013
2	Renal Cell Carcinoma (Grawitz Tumor) 07/2011 - 09/2007
2	Brain Edema (Cerebral Edema) 03/2009 - 07/2002
2	Neurologic Manifestations (Neurological Manifestations) 09/2007 - 01/2004
1	Hypoxia (Hypoxemia) 01/2022

Drug/Important Bio-Agent (IBA)

29	PolymersIBA 02/2015 - 02/2002
27	Carmustine (FIVB)FDA Link 11/2019 - 02/2002
26	Temozolomide (Temodar)FDA LinkGeneric 01/2022 - 10/2005
19	Pharmaceutical PreparationsIBA 02/2021 - 11/2002
11	poliferprosan 20 drug combination carmustine (Gliadel)FDA Link 01/2019 - 01/2004
8	Paclitaxel (Taxol)FDA LinkGeneric 05/2014 - 06/2002
7	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2007
6	decanedioic acid- 4,4'- (1,3- propanediylbis(oxy))bis(benzoic acid) copolymerIBA 02/2013 - 02/2002
5	Biomarkers (Surrogate Marker)IBA 01/2021 - 08/2006
5	CytokinesIBA 03/2016 - 08/2003
5	Interleukin-2 (IL2)IBA 11/2012 - 04/2003
5	Antineoplastic Agents (Antineoplastics)IBA 08/2009 - 02/2002
4	Dexamethasone (Maxidex)FDA LinkGeneric 04/2022 - 01/2004
4	Ribavirin (Virazole)FDA LinkGeneric 02/2021 - 01/2018
4	Monoclonal AntibodiesIBA 12/2018 - 01/2016
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/2017 - 12/2012
4	DNA (Deoxyribonucleic Acid)IBA 08/2015 - 03/2003
4	Alkylating AgentsIBA 01/2015 - 10/2004
3	Glutamic Acid (Glutamate)FDA Link 02/2022 - 10/2013
3	Immune Checkpoint InhibitorsIBA 02/2022 - 01/2018
3	Programmed Cell Death 1 ReceptorIBA 02/2022 - 12/2016
3	Antiviral Agents (Antivirals)IBA 02/2021 - 01/2019
3	Therapeutic UsesIBA 01/2021 - 01/2016
3	Cisplatin (Platino)FDA LinkGeneric 10/2017 - 06/2002
3	Bevacizumab (Avastin)FDA Link 10/2017 - 07/2012
3	AntigensIBA 12/2016 - 01/2014
3	EndostatinsIBA 01/2015 - 11/2005
3	Doxorubicin (Adriamycin)FDA LinkGeneric 11/2014 - 09/2005
3	Anti-Bacterial Agents (Antibiotics)IBA 10/2013 - 11/2005
3	CamptothecinIBA 10/2004 - 02/2002
2	LuciferasesIBA 02/2022 - 06/2013
2	AcriflavineIBA 01/2022 - 11/2017
2	Enhancer of Zeste Homolog 2 ProteinIBA 09/2021 - 02/2021
2	Histone MethyltransferasesIBA 09/2021 - 02/2021
2	Eukaryotic Initiation Factor-4EIBA 02/2021 - 01/2020
2	Thymidine KinaseIBA 01/2020 - 02/2015
2	GuanosineIBA 01/2019 - 01/2018
2	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2018 - 07/2002
2	LigandsIBA 01/2018 - 06/2013
2	Dendrimers (Dendrons)IBA 12/2016 - 06/2015
2	Angiogenesis InhibitorsIBA 01/2016 - 03/2014
2	Messenger RNA (mRNA)IBA 01/2016 - 11/2013
2	Capsules (Microcapsules)IBA 11/2014 - 04/2011
2	Radiation-Sensitizing AgentsIBA 05/2014 - 08/2010
2	Minocycline (Cyclops)FDA LinkGeneric 03/2014 - 09/2003
2	Glucose (Dextrose)FDA LinkGeneric 07/2012 - 05/2010
2	EnzymesIBA 03/2010 - 03/2003
2	Irinotecan (Camptosar)FDA LinkGeneric 08/2006 - 10/2004
2	polilactofateIBA 01/2006 - 08/2003
1	14- methyl- 20- oxa- 5,7,14,26- tetraazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa- 1(25),2(26),3,5,8(27),9,11,16,21,23- decaeneIBA 09/2021
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 09/2021
1	Cyclin D1IBA 09/2021

Therapy/Procedure

59	Therapeutics 01/2022 - 07/2002
26	Drug Therapy (Chemotherapy) 11/2019 - 10/2002
23	Radiotherapy 04/2021 - 01/2004
13	Immunotherapy 02/2022 - 04/2003
10	Craniotomy 01/2022 - 03/2002
4	Microspheres (Microsphere) 05/2014 - 04/2003
3	Length of Stay 03/2022 - 08/2015
2	Reoperation 09/2022 - 10/2018
2	Contraindications 10/2020 - 10/2010
2	Injections 11/2012 - 01/2012
2	Micro-Electrical-Mechanical Systems 08/2012 - 08/2005
2	Oral Administration 03/2010 - 10/2007
1	Patient Readmission 03/2022
1	Laminectomy 02/2022
1	Conservative Treatment 01/2022